解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. It is unknown whether these tasks are spatially zonated along the villus ax...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.08.063
更新日期:2018-11-01 00:00:00
abstract::In familial searching in forensic genetics, a query DNA profile is tested against a database to determine whether it represents a relative of a database entrant. We examine the potential for using linkage disequilibrium to identify pairs of profiles as belonging to relatives when the query and database rely on nonover...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.09.008
更新日期:2018-10-18 00:00:00
abstract::Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction of av...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.08.021
更新日期:2018-10-18 00:00:00
abstract::Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, ind...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.09.004
更新日期:2018-10-18 00:00:00
abstract::Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Recent findings identify key cellular and molecular principles underlying these feats. A stem cell population (neoblasts) generates new cells and is c...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2018.09.021
更新日期:2018-10-04 00:00:00
abstract::Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS, we targeted a promiscuous biotin ligase to cargo-sorting domains on endosome buds. This strategy identified the ER membrane protein TMCC1, a member of ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.08.030
更新日期:2018-09-20 00:00:00
abstract::This year's Albert Lasker Basic Medical Research Award honors David Allis and Michael Grunstein for their pioneering research that highlighted the importance of histones and their post-translational modifications in the direct control of gene expression. ...
journal_title:Cell
pub_type: 传,历史文章,新闻
doi:10.1016/j.cell.2018.08.032
更新日期:2018-09-20 00:00:00
abstract::Much of our understanding of chromosome segregation is based on cell culture systems. Here, we examine the importance of the tissue environment for chromosome segregation by comparing chromosome segregation fidelity across several primary cell types in native and nonnative contexts. We discover that epithelial cells h...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.07.042
更新日期:2018-09-20 00:00:00
abstract::Cell-penetrating peptides (CPPs) are short protein segments that can transport cargos into cells. Although CPPs are widely studied as potential drug delivery tools, their role in normal cell physiology is poorly understood. Early during infection, the L2 capsid protein of human papillomaviruses binds retromer, a cytop...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.07.031
更新日期:2018-09-06 00:00:00
abstract::A key aspect of genomic medicine is to make individualized clinical decisions from personal genomes. We developed a machine-learning framework to integrate personal genomes and electronic health record (EHR) data and used this framework to study abdominal aortic aneurysm (AAA), a prevalent irreversible cardiovascular ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.07.021
更新日期:2018-09-06 00:00:00
abstract::Characterizing cell surface receptors mediating viral infection is critical for understanding viral tropism and developing antiviral therapies. Nevertheless, due to challenges associated with detecting protein interactions on the cell surface, the host receptors of many human pathogens remain unknown. Here, we build a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.06.028
更新日期:2018-08-23 00:00:00
abstract::Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that murine type I SGNs consist of subclasses that are defined by the expression of subsets of transcription factors, cell adhesion molecules...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.07.008
更新日期:2018-08-23 00:00:00
abstract::The mitochondrial unfolded protein response (UPRmt) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.06.029
更新日期:2018-08-09 00:00:00
abstract::There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2018.07.038
更新日期:2018-08-09 00:00:00
abstract::While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.06.039
更新日期:2018-07-26 00:00:00
abstract::RNAs fold into defined tertiary structures to function in critical biological processes. While quantitative models can predict RNA secondary structure stability, we are still unable to predict the thermodynamic stability of RNA tertiary structure. Here, we probe conformational preferences of diverse RNA two-way juncti...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.05.038
更新日期:2018-07-12 00:00:00
abstract::Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles controlling the activation and organization of the actin cytoskeleton during mammalian CME are, however, not fully understood. Here, we show that the protein FCH...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.05.020
更新日期:2018-07-12 00:00:00
abstract::Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural ac...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.04.019
更新日期:2018-06-28 00:00:00
abstract::High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape tumor progression properties at the interface of tumor-infiltrating lymphocytes (TILs) and cancer c...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.073
更新日期:2018-06-14 00:00:00
abstract::Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK12 loss is enriched...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.04.034
更新日期:2018-06-14 00:00:00
abstract::Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how inf...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.04.004
更新日期:2018-05-31 00:00:00
abstract::Post-translational modifications of histone proteins and exchanges of histone variants of chromatin are central to the regulation of nearly all DNA-templated biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we employ a hig...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.079
更新日期:2018-05-31 00:00:00
abstract::T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the capability of CAR T cells, here, we present a split, universal, and programmable (SUPRA) CAR system that simultaneously encompasses multiple ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.038
更新日期:2018-05-31 00:00:00
abstract::Post-translational modification of tubulin offers a mechanism for functional diversification of microtubules and regulation in a variety of physiological contexts. This SnapShot recaps the current state of understanding of tubulin posttranslational modifications and their functions in the regulation of biological proc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.05.032
更新日期:2018-05-31 00:00:00
abstract::The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.05.023
更新日期:2018-05-31 00:00:00
abstract::Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.04.031
更新日期:2018-05-17 00:00:00
abstract::The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that the R201C mutation ca...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.018
更新日期:2018-05-17 00:00:00
abstract::In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.04.016
更新日期:2018-05-03 00:00:00
abstract::Understanding the physiology and genetics of human hypoxia tolerance has important medical implications, but this phenomenon has thus far only been investigated in high-altitude human populations. Another system, yet to be explored, is humans who engage in breath-hold diving. The indigenous Bajau people ("Sea Nomads")...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.054
更新日期:2018-04-19 00:00:00
abstract::Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expressio...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.035
更新日期:2018-04-05 00:00:00
abstract::Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.047
更新日期:2018-04-05 00:00:00
abstract::Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one Denisovan have been sequenced, and these reference genomes have been used to detect introgressed genetic material in present-day human genomes. Segments of introgres...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.031
更新日期:2018-03-22 00:00:00
abstract::H2S is an endogenous gasotransmitter that plays an important role in physiological conditions. In this issue, Das et al. provide evidence that SIRT1-dependent angiogenesis is augmented by H2S-findings reinforced by Longchamp et al., who demonstrate that H2S-dependent angiogenesis is triggered by amino acid deprivation...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.03.011
更新日期:2018-03-22 00:00:00
abstract::Microbial populations can maximize fitness in dynamic environments through bet hedging, a process wherein a subpopulation assumes a phenotype not optimally adapted to the present environment but well adapted to an environment likely to be encountered. Here, we show that oxygen induces fluctuating expression of the tri...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.005
更新日期:2018-03-22 00:00:00
abstract::Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process catalyzed by a specialized membrane-fusion protein expressed on their surface. This review focuses on recent structural studies of viral fusion proteins with an emphasis on their metastable prefusion form and on interactions wi...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2018.02.054
更新日期:2018-03-08 00:00:00
abstract::Plants greatly rely on their root microbiome for uptake of nutrients and protection against stresses. Recent studies have uncovered the involvement of plant stress responses in the assembly of plant-beneficial microbiomes. To facilitate durable crop production, deciphering the driving forces that shape the microbiome ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.024
更新日期:2018-03-08 00:00:00
abstract::Certain mutations can cause proteins to accumulate in neurons, leading to neurodegeneration. We recently showed, however, that upregulation of a wild-type protein, Ataxin1, caused by haploinsufficiency of its repressor, the RNA-binding protein Pumilio1 (PUM1), also causes neurodegeneration in mice. We therefore search...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.006
更新日期:2018-02-22 00:00:00
abstract::The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED micros...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.007
更新日期:2018-02-22 00:00:00
abstract::Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrop...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.01.005
更新日期:2018-02-08 00:00:00
abstract::As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information is generally carried on a circular chromosome with a single origin of replication from which two replication forks proceed bidirectionally toward the opposite terminus region. Here, we investigate the higher-order architecture o...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.12.027
更新日期:2018-02-08 00:00:00